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overall, although the manufacturer argued that in one narrow subset of patients it did. The FDA rejected both drugs, saying that the claims were not strong enough to outweigh the risks to patients. The two manufacturers vowed to return with new and more convincing trials. Meanwhile, the baseline seemed to be that a drug s impact on patients has to last at least a month. In our interview in his office a few months before those rejections, Jesse Goodman agreed that the FDA has to keep rethinking the way it approves drugs and biologics, including the use of smaller trials and different endpoints. We need to be open to study designs and development plans that incorporate new theories, and I think we are, he said. We approach them [by asking], What do we need to know about this product We ve tried to be very open and not prescriptive, thinking about what is the data we really need to understand whether something really works. So, he continued, in some cases that could be smaller trials. To the extent that you can target treatment, if you can define upfront the people who are more likely to benefit, you can do smaller trials. Another is the validation of surrogate endpoints where they are useful. At the same time our job is to protect people.

Initialize: Set ah as in (14.15), and initialize For t = 0, 1, . . . , N - 2 propagate a :

CSS supports many properties for ne control over elements. For example, the following properties all apply to borders: border border-collapse border-spacing border-top border-right border-bottom border-left border-color border-top-color border-right-color border-bottom-color border-left-color border-style border-top-style border-right-style border-bottom-style border-left-style border-width border-top-width border-right-width border-bottom-width border-left-width Several of these properties are shorthand properties, which enable you to set multiple properties at a time. For example, to set an element s border as shown in Figure 17-5, you could use the following de nition:

(12.28)

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We reject the hypothesis and assert that B is better. 10. Hypothesis H0: q25 0. Alternative H1, say, q25 0. If H0 is true, a negative value has probability p 0.25. Reject H0 if fewer than c negative values are observed, where c results from P(X c)H0 . 14. n 5 values, with 2 transpositions, namely, 101.1 before 100.4 and 100.8, so that from Table A12 we obtain P(T 2) 0.117

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This lter reverses the values of an object s hue, saturation, and brightness. It has the following syntax:

for(int i=O;i<isbn.size();i++) { out .psintln("<td><form name=index"+ (i+L) +"method=POSTaction= /servlet/vbs.chapter.ServletBookquerymultsf'); out.println("<input type=hidden name=prevISBN value="+isbn. elementAt (i) + " > " ) ; out.println ( " <a href = \ " / \ '' onclick=\ document. index"+ ( i+l) + 'I . submit(); return false;\">"+(i+l)+"</a>") ; out.println( "</form></td>") ;

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//Find out who from the edit control hwndWho = GetDlgItem(hDlg,IDC_WHO); iTextLen = SendMessage( hwndWho, WM_GETTEXTLENGTH, 0, 0); //require user input if( !iTextLen ) {return FALSE;} //allocate for wide character count plus terminal null lpwszWho = (TCHAR* )LocalAlloc(LPTR, (iTextLen + 1) * sizeof(WCHAR) ); //get the input string SendMessage( hwndWho, WM_GETTEXT, (iTextLen + 1), (LPARAM)(LPSTR)lpwszWho);

With zero transaction cost, the program returns a strategy giving Pardo s profit. This corresponds to property 6 from 2. Profit-and-loss values are identical for r- and l-algorithms. However, the strategies are different because two identical prices, 432.1, can be chosen at different times.

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As you ve seen, the runCommand() function plays a key role in scripting commands. It s worth emphasizing that this same function is used when you want one command to invoke another command. The proper syntax is

When you create a link in Dreamweaver, the anchor pair surrounds the text or object that is being linked. For example, if you link the phrase Back to Home Page, it may look like the following:

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<action path= /goToModifyInvoice type= com.aboutobjects.pitfalls.ModifyInvoiceAction input= /ModifyInvoice.jsp > <forward name= modifyInvoicePage path= /ModifyInvoice.jsp /> </action>

This reuses the PORT definition from the previous section and relabels send to be call and receive to be accept.The server thread is modeled by: SERVER = (entry.~ccept~ch:~]->[ch~->~E~VE~). The server accepts a message from the entry consisting of the name of the reply channelandthenrepliesusingthis charnel name.Rememberthatwemodel synchronous commu~cation a single shared action which is the name of the by charnel. The client is modeled by: CLIENT(CH='reply) = (entry.call[CH] ->~CH]->CLI~NT). where CH is a parameter initialized to the action label ply.In FSP, action labels re used as parameter values or in expressions must be prefixed with a single quote to CL1 distinguish them from variables. The ENT process sends this parameter, which names the reply channel, to the entry and then waits for the reply. The composite model describing the demonstration program is shown in Figure 10.12.

-1.2 50 1.2 100 150 200 0 50

The last style won t appear to have any effect until you preview the page in a browser or switch to Live view, as shown in Figure 15-12.

show restraint when splitting and merging cells, or your table will be difficult to maintain. When you are building a complex table such as the one in Figure 13-13, it s best to map out your table before you begin constructing it and to complete it prior to entering your data.